Let’s be clear: Larry Cohen‘s The Stuff isn’t anyone would call a good movie, but it is a damn interesting one. What it has going for it is a timely premise (the idea of consumerism run rampant combined with corporate and government malfeasance) and some very interesting special effects.
The movie plays like a twisted version of Dan Siegel’s Invasion Of The Body Snatchers (speaking of which, Invasion Of The Body Snatchers is one of the few films that has benefitted from multiple remakes; The Invasion, notwithstanding) but with a more culinary bent in that a white substance is found bubbling from the earth, that happens to be edible. This mysterious foodstuff, marketed as The Stuff, takes the country by storm, making some people very rich.
But there’s a problem. The company selling it has co-opted the some scientists in the FDA (the Food and Drug Administration), so that no one quite knows what’s in The Stuff, which is a very bad thing because The Stuff is alive. It’s similar to yogurt, except with a will, and a drive all its own.
In other words, when you eat it, it eats you.

A possible angle for a reboot could take would make the stuff called ‘The Stuff’ a genetically modified organism (GMO), as opposed to a naturally-occuring one, giving new meaning to the phrase “smart food.”
What needs to remain is the practical nature of the special effects. There’s something significantly creepy about the mouth of a animatronic head opening wider than humanly possible, as opposed the way such things are typically done with CGI, which more often than not look like a video game (See: I Am Legend).
Since the movie falls apart somewhere around the midway point, when Paul Sorvino turns up as a disgraced military commander–curiously similar to quite a few Right wing radio hosts–I would chuck that entire subplot and instead concentrate on how futile it it would first seem for people who haven’t been co-opted.
That way, the entire film would focus on the efforts of a disgraced FBI agent working against the odds to unmask the horror of The Stuff.